Suchergebnisse
Filter
11 Ergebnisse
Sortierung:
World Affairs Online
The golden century of oil, 1950 - 2050: the depletion of a resource
In: The GeoJournal Library 19
Recognising the Second Half of the Oil Age
In: Environmental innovation and societal transitions, Band 9, S. 13-17
ISSN: 2210-4224
Beyond Historical Tragedy: The Frankfurt School and Judeo-Christian Messianism
In: Strategies of critique: a graduate journal of social and political thought
ISSN: 1916-7210
In "Beyond Historical Tragedy" the author compares and discusses Hegel's prescient understanding of the meaning of tragedy and how it differs from Aristotelian or quasi-Aristotelian theories. At the same time, he embarks on a critique of George Steiner's Hegelian reading of Sophocles' Antigone, and of tragedy more generally. He develops the idea that the Critical Theory of the Frankfurt School is closer to a Jewish or Christian perspective than to the tragic perspective - or to Hegel's modern version of the tragic perspective. The contrast is most clear in the way that the idea of fate is negated by Adorno, Horkheimer, Marcuse and Benjamin.
Excess, Apocalypse and Crisis: Religious and Political Visions in Bataille, Girard and Critical Theory
In: Western Political Science Association 2010 Annual Meeting Paper
SSRN
Working paper
The Peak and Decline of World Oil and Gas Production
In: Minerals & energy: raw materials report, Band 18, Heft 1, S. 5-20
ISSN: 1651-2286
Sustainability transition and economic growth enigma: Money or energy?
In: Environmental innovation and societal transitions, Band 9, S. 8-12
ISSN: 2210-4224
Antitumour activity of the novel flavonoid oncamex in preclinical breast cancer models
We thank SULSA (Scottish Universities Life Science Alliance) for supporting this project through a SULSA BioSkape Industry PhD Studentship and Antoxis Limited for providing additional funding. We also thank the 7th Framework Programme of the European Union (METOXIA project; HEALTH-F2-2009-222741) for support. ; Background: The natural polyphenol myricetin induces cell cycle arrest and apoptosis in preclinical cancer models. We hypothesised that myricetin-derived flavonoids with enhanced redox properties, improved cell uptake and mitochondrial targeting might have increased potential as antitumour agents. Methods: We studied the effect of a second-generation flavonoid analogue, Oncamex, in a panel of 7 breast cancer cell lines, applying western blotting, gene expression analysis, fluorescence microscopy, and immunohistochemistry to xenograft tissue to investigate its mechanism of action. Results: Proliferation assays showed that Oncamex: treatment for 8 h reduced cell viability and induced cytotoxicity and apoptosis, concomitant with increased caspase activation. Microarray analysis showed that Oncamex was associated with changes in expression of genes controlling cell cycle and apoptosis . Fluorescence microscopy showed the compound's mitochondrial targeting and ROS-modulating properties, inducing superoxide production at concentrations associated with anti-proliferative effects. A preliminary in vivo study in mice implanted with the MDA-MB-231 breast cancer xenograft showed that Oncamex inhibited tumour growth, reduced tissue viability and Ki-67 proliferation, with no overall systemic toxicity. Conclusion: Oncamex is a novel flavonoid capable of specific mitochondrial delivery and redox modulation. It has shown antitumour activity in preclinical models of breast cancer, supporting the potential of this prototypic candidate for its continued development as an anticancer agent. ; Publisher PDF ; Peer reviewed
BASE